{"id":11919,"date":"2021-01-29T00:00:00","date_gmt":"2021-01-28T16:00:00","guid":{"rendered":"https:\/\/news.dukekunshan.edu.cn\/research-news\/research-brings-dku-professor-edge-medical-breakthrough\/"},"modified":"2021-01-29T00:00:00","modified_gmt":"2021-01-28T16:00:00","slug":"research-brings-dku-professor-edge-medical-breakthrough","status":"publish","type":"research_news","link":"https:\/\/news.dukekunshan.edu.cn\/zh-hans\/research-news\/research-brings-dku-professor-edge-medical-breakthrough\/","title":{"rendered":"RNA \u6280\u672f\u52a9\u529b\u6606\u5c71\u675c\u514b\u5927\u5b66\u7684\u533b\u7597\u7814\u7a76\u5f00\u7586\u62d3\u571f"},"content":{"rendered":"

\"\"
\n
\u9ec4\u6797\u5cf0\u5728\u6606\u5c71\u675c\u514b\u5927\u5b66\u7684\u5b9e\u9a8c\u5ba4<\/em><\/img><\/p>\n

\u6587 | John Butcher<\/strong><\/p>\n

\u8fd1\u671f\u6570\u6708\uff0c\u6838\u7cd6\u6838\u9178(RNA)\u7597\u6cd5\u56e0\u5176\u5728\u65b0\u51a0\u80ba\u708e\u75ab\u82d7\u4e2d\u7684\u9891\u7e41\u5e94\u7528\u8fc5\u901f\u6210\u4e3a\u56fd\u9645\u65b0\u95fb\u4e2d\u7684\u70ed\u70b9\uff0c\u4f46\u4eba\u4eec\u5bf9\u8fd9\u4e00\u65b0\u5174\u533b\u7597\u6280\u672f\u5728\u4e9a\u6d32\u7684\u7814\u53d1\u5374\u77e5\u4e4b\u751a\u5c11\u3002\u4e0d\u8fc7\u4e8b\u5b9e\u4e0a\u8bb8\u591a\u4e13\u7cbe\u4e8e RNA \u6280\u672f\u7814\u7a76\u7684\u673a\u6784\u4e0e\u4f01\u4e1a\u90fd\u5904\u4e8e\u8fd9\u4e00\u5730\u5e26\uff0c\u6bd4\u5982\u4e13\u4e1a\u4ece\u4e8b\u57fa\u4e8e RNA \u5e72\u6270\u6280\u672f\u7684\u6838\u9178\u836f\u7269\u7814\u53d1\u7684\u9876\u5c16\u9ad8\u65b0\u6280\u672f\u4f01\u4e1a\u2014\u2014\u82cf\u5dde\u745e\u535a\u751f\u7269\u6280\u672f\u6709\u9650\u516c\u53f8\u5c31\u5750\u843d\u5728\u4e2d\u56fd\u6c5f\u82cf\u7701\u7684\u6606\u5c71\u5e02\u5185\uff0c\u4e0e\u5176\u76f8\u90bb\u7684\u8fd8\u6709\u4e00\u7cfb\u5217 RNA \u6280\u672f\u516c\u53f8\u4ee5\u53ca\u6606\u5c71\u675c\u514b\u5927\u5b66\u751f\u7269\u5b66\u526f\u6559\u6388\u9ec4\u6797\u5cf0\u535a\u58eb\u7684\u5b9e\u9a8c\u5ba4\uff0c\u5728\u8fd9\u4e2a\u5b9e\u9a8c\u5ba4\u91cc\u9ec4\u6797\u5cf0\u535a\u58eb\u4e00\u76f4\u4e13\u6ce8\u4e8e RNA \u5f3a\u5927\u751f\u7269\u6280\u672f\u548c\u6cbb\u7597\u6cd5\u7814\u7a76\u7684\u6700\u524d\u6cbf\u3002<\/p>\n

\u9ec4\u6797\u5cf0\u535a\u58eb\u6295\u5165\u5341\u591a\u5e74\u7684\u65f6\u95f4\u6765\u7814\u7a76RNA \u76f8\u5173\u79d1\u6280\u5728\u9884\u9632\u9057\u4f20\u75be\u75c5\u548c\u5236\u9020\u73af\u4fdd\u519c\u836f\u4e2d\u7684\u5e94\u7528\u3002\u4ed6\u5373\u5c06\u7814\u53d1\u51fa\u4e00\u9879\u80fd\u4f7f RNA \u751f\u4ea7\u901f\u5ea6\u52a0\u5feb\u5e76\u4e14\u6210\u672c\u66f4\u4f4e\u3001\u5236\u9020\u66f4\u5bb9\u6613\u7684\u6280\u672f\uff0c\u4ece\u800c\u5927\u5927\u589e\u52a0\u672a\u6765\u5bf9RNA\u7684\u4f7f\u7528\uff1b\u9ec4\u6797\u5cf0\u535a\u58eb\u8868\u793a\uff1a\u201c\u8fd9\u5c06\u662f\u9996\u4e2a\u5229\u7528\u7ec6\u83cc\u53d1\u9175\u751f\u4ea7\u4e00\u79cd\u9ad8\u529f\u80fdRNA\u7684\u751f\u7269\u5de5\u7a0b\u6280\u672f\u3002\u201d<\/p>\n

RNA\u662f\u8fde\u63a5DNA\uff08\u8131\u6c27\u6838\u7cd6\u6838\u9178\uff09\u548c\u86cb\u767d\u8d28\u7684\u5173\u952e\u9057\u4f20\u7269\u8d28\uff0c\u800cRNA\u7597\u6cd5\u662f\u6307\u4f7f\u7528RNA\u7528\u4e8e\u75ab\u82d7\u548c\u6cbb\u7597\u5404\u79cd\u75be\u75c5\uff0c\u662f\u4e00\u4e2a\u6b63\u5728\u84ec\u52c3\u53d1\u5c55\u7684\u533b\u5b66\u65b9\u5411\u3002\u5728\u88ab\u7d27\u6025\u6279\u51c6\u7528\u4e8e\u65b0\u51a0\u75ab\u82d7\u4e4b\u524d\uff0cRNA\u7597\u6cd5\u4ec5\u7528\u4e8e\u5c11\u6570\u6cbb\u7597\u9057\u4f20\u75c5\u7684\u836f\u7269\u4e2d\u3002<\/p>\n

\u9ec4\u6797\u5cf0\u535a\u58eb\u7684\u7814\u7a76\u91cd\u70b9\u662f\u5236\u9020\u5c0f\u7247\u6bb5RNA\uff0c\u4ece\u800c\u901a\u8fc7\u9776\u5411\u4fe1\u4f7fRNA\uff08mRNA\uff09\uff0c\u5373\u4e0e\u57fa\u56e0\u9057\u4f20\u5e8f\u5217\u76f8\u5bf9\u5e94\u7684\u5355\u94feRNA\u5206\u5b50\uff0c\u6291\u5236\u57fa\u56e0\u8868\u8fbe\u6216\u5173\u95ed\u529f\u80fd\u5931\u5e38\u7684\u57fa\u56e0\u3002\u4eba\u9020mRNA\u8fd8\u53ef\u4ee5\u7528\u6765\u5728\u4eba\u4f53\u5185\u4ea7\u751f\u989d\u5916\u7684\u86cb\u767d\u8d28\uff0c\u4ee5\u8bf1\u5bfc\u514d\u75ab\u53cd\u5e94\u6216\u8865\u507f\u67d0\u79cd\u57fa\u56e0\u7684\u7f3a\u4e4f\u3002<\/p>\n

\u9ec4\u6797\u5cf0\u535a\u58eb\u8868\u793a\uff0c\u4e0e\u5176\u4ed6\u6cbb\u7597\u65b9\u5f0f\u6216\u836f\u7269\u76f8\u6bd4\uff0cRNA\u7597\u6cd5\u7684\u4f18\u52bf\u5728\u4e8e\u8bbe\u8ba1\u548c\u751f\u4ea7\u65b9\u4fbf\uff0c\u529f\u80fd\u66f4\u660e\u786e\uff0c\u526f\u4f5c\u7528\u66f4\u5c0f\uff0c\u8fd9\u4e5f\u4f7f\u5f97\u5176\u6548\u679c\u666e\u904d\u66f4\u597d\u3002<\/p>\n

\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u201c\u4f20\u7edf\u7684\u836f\u7269\uff0c\u4e3b\u8981\u662f\u86cb\u767d\u8d28\u548c\u5316\u5b66\u5c0f\u5206\u5b50\uff0c\u9009\u62e9\u548c\u5f00\u53d1\u90fd\u5f88\u56f0\u96be\uff0c\u800c\u4e14\u5bf9\u4e8e\u5f88\u591a\u4f20\u7edf\u836f\u7269\u6765\u8bf4\uff0c\u7814\u7a76\u4eba\u5458\u4e5f\u4e0d\u6e05\u695a\u5b83\u4eec\u5230\u5e95\u662f\u5982\u4f55\u53d1\u6325\u4f5c\u7528\u7684\u3002\u201d<\/p>\n

RNA\u7597\u6cd5\u7684\u7f3a\u70b9\u662f\u5408\u6210RNA \u201c\u6781\u4e0d\u7a33\u5b9a\u201d\uff0c\u751f\u4ea7\u6210\u672c\u9ad8\uff0c\u540c\u65f6RNA\u662f\u751f\u7269\u5927\u5206\u5b50\uff0c\u96be\u4ee5\u8f7b\u6613\u7a7f\u8fc7\u7ec6\u80de\u819c\u8fdb\u5165\u7ec6\u80de\uff0c\u5230\u8fbe\u76ee\u6807\u5668\u5b98\u3002<\/p>\n

\u513f\u65f6\u7684\u68a6\u60f3<\/strong><\/p>\n

\u9ec4\u6797\u5cf0\u535a\u58eb\u4e00\u76f4\u90fd\u7740\u8ff7\u4e8e\u79d1\u5b66\u7814\u7a76\u3002\u201c\u6211\u4ece\u5c0f\u5c31\u5bf9\u79d1\u5b66\u5145\u6ee1\u4e86\u597d\u5947\u548c\u70ed\u60c5\uff0c\u68a6\u60f3\u6210\u4e3a\u4e00\u540d\u79d1\u5b66\u5bb6\u3002\u201d<\/p>\n

2003\u5e74\uff0c\u4ed6\u83b7\u5f97\u4e2d\u56fd\u519c\u4e1a\u5927\u5b66\u751f\u7269\u79d1\u5b66\u5b66\u9662\u5b66\u58eb\u5b66\u4f4d\uff0c\u513f\u65f6\u7684\u68a6\u60f3\u521d\u5177\u96cf\u5f62\u3002<\/p>\n

\u9ec4\u6797\u5cf0\u968f\u540e\u6765\u5230\u82f1\u56fd\u725b\u6d25\u5e02\uff0c\u6210\u4e3a\u82f1\u56fd\u751f\u6001\u4e0e\u6c34\u6587\u4e2d\u5fc3(U.K. Centre for Ecology and Hydrology)\u738b\u6656\u535a\u58eb\u8bfe\u9898\u7ec4\u7684\u8bbf\u95ee\u7814\u7a76\u5458\uff0c\u4e4b\u540e\u53c8\u5728\u4f4d\u4e8e\u82f1\u683c\u5170\u4e1c\u90e8\u8bfa\u91cc\u5947\u5e02\u7684\u7ea6\u7ff0\u00b7\u82f1\u5c3c\u65af\u4e2d\u5fc3(JIC)\u585e\u6069\u65af\u4f2f\u91cc\u5b9e\u9a8c\u5ba4(Sainsbury Laboratory)\u653b\u8bfb\u4e86\u56db\u5e74\u535a\u58eb\u5b66\u4f4d\uff0c\u5e08\u4ece\u82f1\u56fd\u8457\u540d\u690d\u7269\u79d1\u5b66\u5bb6\u548c\u9057\u4f20\u5b66\u5bb6\u5927\u536b\u00b7\u9c8d\u5c14\u79d1\u59c6\u7235\u58eb(David Baulcombe)\u3002<\/p>\n

\u5728\u653b\u8bfb\u535a\u58eb\u671f\u95f4\uff0c\u9ec4\u6797\u5cf0\u5f00\u59cb\u5bf9RNA\u4ea7\u751f\u4e86\u5174\u8da3\uff0c\u5e76\u7740\u624b\u7814\u7a76\u4e00\u79cd\u65b0\u53d1\u73b0\u7684\u3001\u5177\u6709\u690d\u7269\u7279\u5f02\u6027\u5e76\u4e14\u4f9d\u8d56DNA\u7684RNA\u805a\u5408\u9176\u3002\u5728\u585e\u6069\u65af\u4f2f\u91cc\u5b9e\u9a8c\u5ba4\uff0c\u9ec4\u6797\u5cf0\u9996\u5148\u63ed\u793a\u4e86\u8fd9\u79cd\u65b0\u578bRNA\u805a\u5408\u9176\u7684\u751f\u5316\u7279\u6027\uff0c\u5e76\u5f00\u59cb\u5c06\u7814\u7a76\u91cd\u70b9\u805a\u7126\u4e8eRNA\u5e72\u6270(RNAi)\u7684\u751f\u7269\u5b66\u539f\u7406\u548c\u6280\u672f\u5e94\u7528\uff0cRNA\u5e72\u6270\u662f\u6539\u53d8\u57fa\u56e0\u6d3b\u6027\u7684\u4e00\u79cd\u81ea\u7136\u624b\u6bb5\u3002<\/p>\n

\u6b64\u540e\uff0c\u9ec4\u6797\u5cf0\u535a\u58eb\u63a2\u7d22\u4e86\u591a\u4e2a\u7814\u7a76\u8bfe\u9898\uff0c\u5305\u62ec\u751f\u4ea7\u57fa\u4e8eRNA\u7684\u764c\u75c7\u836f\u7269\uff0c\u5e76\u7814\u7a76RNA\u5728\u5e94\u5bf9\u5be8\u5361\u75c5\u6bd2\u3001\u4e00\u79cd\u4f1a\u5bfc\u81f4\u65b0\u751f\u513f\u5c0f\u5934\u7578\u5f62\u548c\u5176\u4ed6\u5148\u5929\u6027\u7578\u5f62\u7684\u75c5\u6bd2\u611f\u67d3\u65b9\u9762\u7684\u7528\u9014\u3002 2018\u5e74\uff0c\u9ec4\u6797\u5cf0\u535a\u58eb\u6210\u4e3a\u751f\u7269\u6280\u672f\u521b\u4e1a\u8005\uff0c\u5728\u9999\u6e2f\u79d1\u6280\u56ed\u521b\u5efa\u4e86\u5c0f\u9ed8\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff0c\u5229\u7528\u4ed6\u53d1\u660e\u7684\u6280\u672f\u201c\u5f00\u53d1\u9769\u547d\u6027\u7684RNA\u5e72\u6270\u4ea7\u54c1\uff0c\u7528\u4e8e\u836f\u7269\u53d1\u73b0\u548c\u519c\u4e1a\u5e94\u7528\uff0c\u5bf9RNA\u5e72\u6270\u6280\u672f\u5e02\u573a\u4ea7\u751f\u91cd\u5927\u5f71\u54cd\u3002\u201d<\/p>\n

\"\"<\/img><\/p>\n

2019\u5e74\uff0c\u9ec4\u6797\u5cf0\u535a\u58eb\u4e0e\u4ed6\u5728\u62c5\u4efb\u9999\u6e2f\u57ce\u5e02\u5927\u5b66\u751f\u7269\u533b\u5b66\u7cfb\u526f\u6559\u6388\u65f6\u671f\u7684\u540c\u4e8b\u5728RNA\u7597\u6cd5\u7814\u53d1\u65b9\u9762\u53d6\u5f97\u4e86\u91cd\u8981\u8fdb\u5c55\u3002\u4ed6\u4eec\u5f00\u53d1\u4e86\u4e00\u79cd\u9ad8\u6548\u7684\u5c0f\u5e72\u6270RNA(siRNA) \u4f20\u9001\u5de5\u5177\uff0c\u7528\u4e8e\u764c\u75c7\u8054\u5408\u6cbb\u7597\uff0c\u514b\u670d\u4e86\u8be5\u5e94\u7528\u96be\u4ee5\u4f20\u9001\u7ed9\u75c5\u60a3\u7684\u5c40\u9650\u6027\u3002\u76ee\u524d\uff0c\u5728\u6606\u5c71\u675c\u514b\u5927\u5b66\u7684\u5b9e\u9a8c\u5ba4\u91cc\uff0c\u9ec4\u6797\u5cf0\u535a\u58eb\u6b63\u5904\u4e8e\u65b0\u7a81\u7834\u7684\u8fb9\u7f18\uff0c\u5f88\u53ef\u80fd\u4f1a\u8fdb\u4e00\u6b65\u63a8\u52a8\u8fd9\u4e00\u65b0\u5174\u6280\u672f\u7684\u5f00\u53d1\u548c\u5e94\u7528\u3002<\/p>\n

\u9ec4\u6797\u5cf0\u535a\u58eb\u548c\u56e2\u961f\u5df2\u7ecf\u8bc1\u660e\u4e86\u5229\u7528\u7ec6\u83cc\u53d1\u9175\u8fdb\u884c\u5927\u89c4\u6a21\u751f\u4ea7siRNA\u7684\u80fd\u529b\u3002\u4ece\u672c\u8d28\u4e0a\u8bb2\uff0c\u8fd9\u6d89\u53ca\u5230\u5229\u7528\u5fae\u751f\u7269\u751f\u4ea7\u5408\u6210RNA\u3002\u8fd9\u9879\u88ab\u4ed6\u5f62\u5bb9\u4e3a\u201c\u5c31\u50cf\u53d1\u9175\u5564\u9152\u4e00\u6837\u201d\u7684\u6280\u672f\u53ef\u4ee5\u5728\u4efb\u4f55\u5730\u65b9\u66f4\u4fbf\u5b9c\u4e5f\u66f4\u5bb9\u6613\u5f97\u8fdb\u884c\u751f\u4ea7\uff0c\u8fd9\u4e5f\u610f\u5473\u7740\u5c06\u51cf\u5c11\u8fd0\u8f93\u9700\u6c42\u3002<\/p>\n

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